Trabexus is a proprietary¹, biocompatible, self-setting, gradually resorbable, calcium phosphate matrix enhanced with partially demineralized allograft particles. Partial demineralization of allograft has been shown to expose key osteoinductive proteins that can influence and direct bone repair.

Trabexus is supplied as a multi-component, sterile, single use kit. After briefly mixing the product components at the point of use, the material will transform into a paste and remain workable for up to 4.5 minutes. Upon setting, the calcium phosphate component will convert to hydroxyapatite, the mineral composition of native human bone. Trabexus is resorbed and remodeled by the body as new bone formation occurs during the healing process.

Trabexus is intended for use to fill bony voids or defects of the skeletal system (i.e. extremities, pelvis) that may be surgically created or osseous defects created from traumatic injury to the bone.

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Trabexus or Trabecular Osteoinductive Biocement is a self-setting calcium phosphate matrix with engineered allograft bone particles for optimized compressive strength and resorptive characteristics. Mixing instructions for Trabexus are detailed in this video.

Trabecular osteoinductive biocement² is a self-setting calcium phosphate matrix with engineered allograft bone particles for optimized compressive strength and resorptive characteristics.

Trabs® viewed under high magnification, partially demineralized layer is clearly visible on outer surface.

Trabs® prior to mixing with calcium phosphate.

The cornerstone of Trabexus is the thoughtful design of the allograft component. In Trabexus, the allograft component is formed into “hourglass” shapes (known as Trabs) using a proprietary manufacturing process.

This novel shape provides multiple benefits, including increased “interconnectivity” of adjacent particles, creation of channels for accelerated remodeling and greater overall surface area.

These factors optimize the ratio of compressive strength to allograft content. The Trabs are partially demineralized, exposing key osteoinductive proteins, while preserving a core of mineralized cortical bone allograft, which further optimizes the product’s resorption characteristics.

Surgically created bone defects in a rabbit model were filled with Trabexus and compared to defects filled with standard calcium phosphate cement. 8 weeks post surgery, Trabexus filled defects demonstrate signs of cell infiltration and remodeling.

Trabexus

Standard Cement