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Acumed is the exclusive distributor for Trabexus. Click here for more information from the manufacturer. All products displayed on this page are manufactured by Vivorté. If you have any questions, comments, or complaints about products displayed on this page, please contact Vivorté directly.
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Product Overview

Trabexus is a proprietary1, biocompatible, self-setting, gradually resorbable, calcium phosphate matrix enhanced with partially demineralized allograft particles. Partial demineralization of allograft has been shown to expose key osteoinductive proteins that can influence and direct bone repair.

Trabexus is supplied as a multi-component, sterile, single use kit. After briefly mixing the product components at the point of use, the material will transform into a paste and remain workable for up to 4.5 minutes. Upon setting, the calcium phosphate component will convert to hydroxyapatite, the mineral composition of native human bone. Trabexus is resorbed and remodeled by the body as new bone formation occurs during the healing process.

Trabexus is intended for use to fill bony voids or defects of the skeletal system (i.e. extremities, pelvis) that may be surgically created or osseous defects created from traumatic injury to the bone.


Performance Characteristics

  • Composition

    Resorbable calcium phosphate matrix with partially demineralized allograft particles “Trabs”

  • Compressive strength

    25MPa

  • Osteoconductive

    Material crystallizes into hydroxyapatite upon setting, the mineral phase of native human bone

  • Osteoinductive

    Allograft component is partially demineralized, exposing key osteoinductive proteins

  • Resorption Profile

    More rapid compared to calcium phosphate cements

  • Thermal stability

    Does not require refrigeration prior to use

  • Resistant to lavage

    Solidifies in a wet field

  • Sizes

    3cc, 5cc, 10cc


Related Documents

The documents presented here are produced and maintained by Vivorte. For more information about the manufacturer, click here.

Video: Mixing Instructions

Trabexus or Trabecular Osteoinductive Biocement is a self-setting calcium phosphate matrix with engineered allograft bone particles for optimized compressive strength and resorptive characteristics. Mixing instructions for Trabexus are detailed in this video.
Download the video

Trabs Explained

Trabecular osteoinductive biocement2 is a self-setting calcium phosphate matrix with engineered allograft bone particles for optimized compressive strength and resorptive characteristics.

Standard Volar Distal Radius Plates
Trabs® viewed under high magnification, partially demineralized layer is clearly visible on outer surface.
Standard Volar Distal Radius Plates
Trabs® prior to mixing with calcium phosphate.

The Optimal Bone Void Filler

The cornerstone of Trabexus is the thoughtful design of the allograft component. In Trabexus, the allograft component is formed into “hourglass” shapes (known as Trabs) using a proprietary manufacturing process.

This novel shape provides multiple benefits, including increased “interconnectivity” of adjacent particles, creation of channels for accelerated remodeling and greater overall surface area.

These factors optimize the ratio of compressive strength to allograft content. The Trabs are partially demineralized, exposing key osteoinductive proteins, while preserving a core of mineralized cortical bone allograft, which further optimizes the product’s resorption characteristics.

Trabexus Trab properties

Cell Infiltration and Remodeling

Surgically created bone defects in a rabbit model were filled with Trabexus and compared to defects filled with standard calcium phosphate cement. 8 weeks post surgery, Trabexus filled defects demonstrate signs of cell infiltration and remodeling.
Trabexus
Trabexus
Standard cement
Standard Cement

Citations

1. Trabexus is covered by United States patents 9,072,720 and 10,046,090.

2. Allograft component demonstrated osteoinductivity in athymic mouse model submitted for 510(k). Refer to 510(k) summary K143547. Data on file at Vivorté, Inc.

GFS-00090-02