ProModel Bone Void Filler is a synthetic bone graft made from a proprietary matrix of calcium phosphate, calcium sulfate and pore-generating fillers that is indicated for bone voids or gaps of the skeletal system that are not intrinsic to the stability of the bone structure. ProModel Bone Void Filler resorbs and is replaced by bone during the healing process. In an animal study conducted on sheep, the addition of the calcium sulfate to calcium phosphate provided a more porous construct at 4 and 12 weeks assessment, while still maintaining the structural geometry of the implant. ProModel Bone Void Filler undergoes two stages en route to remodeling into natural cancellous bone. The first stage, approximately 15 to 60 days after implantation, consists of dissolution of the porogens, resulting in a macroporous calcium phosphate construct. During this stage, the macropores allow the patient’s natural bone remodeling cells (osteoclasts and osteoblasts) a greater surface area to begin remodeling the product into bone. The second stage consists of cell-mediated remodeling of this macroporous calcium phosphate construct and can take 12 to 24 months.
|Document Title||Document Type||Language||Published||Updated|
|ProModel Surgical Technique (BIO00-04-D)||Surgical Technique||English EN||September 24, 2013||September 11, 2015|